Tumor necrosis factor-alpha (TNF-alpha) promotes cell survival during spermatogenesis, and this effect can be blocked by infliximab, a TNF-alpha antagonist

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EXPERIMENTAL STUDY Tumor necrosis factor-alpha (TNF-a) promotes cell survival during spermatogenesis, and this effect can be blocked by infliximab, a TNF-a antagonist

Objective: Tumor necrosis factor-alpha (TNF-a) has been shown to inhibit germ cell death in human seminiferous epithelium. In the present study, we wanted to explore the effects of TNF-a in the rat seminiferous epithelium and to study molecular mechanisms of germ cell apoptosis. Furthermore, the effects of infliximab were studied. Infliximab is a TNF-a antagonist used in autoimmune disorders, s...

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TUMOR NECROSIS FACTOR ALPHA (TNF-a)

Tumor necrosis factor alpha (TNF, TNFSF2) is an important multifunctional cytokine that regulates inflammation, host defense, immune responses, and apoptosis. TNF exists as a membrane-bound 26kDa, type II integral membrane protein, and a 17kDa soluble homotrimeric TNF that is generated via proteolytic cleavage by TNF-a converting enzyme (TACE, ADAM17). Both the membrane-bound and soluble forms ...

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The paradoxical effect of tumor necrosis factor alpha (TNF-alpha) in endotoxin-induced uveitis.

PURPOSE To investigate the role of TNF-alpha in endotoxin-induced uveitis (EIU) in mice. METHODS To neutralize TNF-alpha activity, mice were pretreated with either repeated injections of this cytokine or a single injection of antibody against it. The mice were then injected intraperitoneally with 500 micrograms endotoxin, to induce lethal septic shock, or into the footpad with 200 micrograms ...

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Stimulation of fibroblast chemotaxis by human recombinant tumor necrosis factor alpha (TNF-alpha) and a synthetic TNF-alpha 31-68 peptide

Macrophages are a major source of fibrogenic factors that promote healing of injured tissue. The recruitment of fibroblasts to sites of tissue injury is a prerequisite for optimal repair of tissue damage. In the present study, human recombinant tumor necrosis factor alpha (hrTNF-alpha), a major macrophage-derived cytokine, was demonstrated to be a potent fibroblast chemoattractant, inducing mig...

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Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2

INTRODUCTION Elevated serum levels of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) correlate with an increased risk for atherothrombotic events and TNFα is known to induce prothrombotic molecules in endothelial cells. Based on the preexisting evidence for the impact of TNFα in the pathogenesis of autoimmune disorders and their known association with an acquired hypercoagulabi...

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ژورنال

عنوان ژورنال: European Journal of Endocrinology

سال: 2004

ISSN: 0804-4643,1479-683X

DOI: 10.1530/eje.0.1510629